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钬激光诱导空化气泡及组织消融的实验研究
Experimental study on holmium laser-induced cavitation bubble and tissue ablation
投稿时间:2022-04-29  修订日期:2022-06-22
DOI:
中文关键词:  钬激光  空化气泡  激光消融  结石
英文关键词:holmium laser? cavitation bubble? laser ablation? calculus
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)
作者单位邮编
徐云飞 顶峰多尺度科学研究所 610031
边雅龙 顶峰多尺度科学研究所 610031
张玉锋 西南交通大学物理科学与技术学院 610031
曹扬 成都市第三人民医院 610072
罗胜年 西南交通大学材料科学与工程学院 610031
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中文摘要:
      为揭示高能量激光脉冲诱导气泡空化的机理及其在组织消融中的应用前景,通过自主研制Ho:YAG激光器开展了大量激光诱导气泡空化的实验并将其应用于真实结石的消融过程。通过高速摄影获取了空化气泡的演变过程,量化了空泡尺寸随时间的演化过程以及不同激光脉冲能量下空泡体积最大时的形状和尺寸。空化气泡的演变过程包括成核、膨胀、坍塌和反弹等多个阶段,随着时间增加会反复膨胀和坍塌,由于气泡能量急剧衰减,气泡的最大尺寸也迅速减小。随着激光脉冲能量的增加,最大空化气泡的尺寸逐渐增加,整体形状从近似球形逐渐变为椭球形。最后,利用高能激光开展了真实结石的消融实验并对消融后形貌进行了量化表征,光学和形貌照片表明激光脉冲产生了由水蒸气和结石碎片形成的烧蚀羽流并在结石表面形成碗状深坑,这是气泡空化和光热消融共同作用的结果。钬激光对于结石组织具有较好的消融效果,可适当提高钬激光能量以达到更好的临床应用效果。
英文摘要:
      In order to reveal the mechanism of laser-induced bubble cavitation and application in hard tissue ablation by high laser pulses, laser-induced cavitation experiments are carried out with a home-made Ho:YAG laser. The morphology evolution of cavitation bubbles and the dimensions of the bubbles with the largest volume at different laser pulse energies are characterized with high-speed imaging. Multiple stages are observed in the cavitation and bubbling process, i.e., nucleation, expansion, collapse and re-expansion. The bubble expands and collapses repeatedly, and the maximum size of bubbles decreases rapidly due to the rapid attenuation of bubble energy. In addition, the shape of the largest bubble evolves from nearly spherical to ellipsoidal as the laser pulse energy increases. Finally, the high-energy laser is applied to ablation of human calculi. The optical and surface images show that laser pulses produce plumes consisting of air and fragments and bowl-shaped craters on the ablated calculus surfaces. This is a combined result of laser-induced bubble cavitation and photothermal ablation. Holmium laser has a good effect on calculus ablation, which can appropriately increase the holmium laser pulse energy to achieve better clinical application.
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