This study focuses on a single crystal superalloy DD6, aiming to investigate the influence of thin-walled characteristics on the VHCF performance. The influence of wall thickness and test temperature on the VHCF performance and failure mechanism were investigated. Firstly, three types of thin-walled specimens with different thicknesses (0.5 mm, 1.0mm and 1.5mm) were designed for testing at room temperature and high temperature. Then, a high-temperature vibration fatigue experimental system was established for the thin-walled specimens. Vibration fatigue experiments were conducted at room temperature and 850 ℃, respectively. The fatigue S-N curve with a maximum cycle number of 109 cycles was obtained, and compared with the results of rotational bending fatigue at the same temperature. Finally, the influence of thickness and temperature on the fatigue performance of thin-walled specimens was analyzed. The results show that the fatigue strength of the 0. 5 mm thin-walled specimen is the highest under room temperature conditions, and no thickness debit effect is observed. But the fatigue strength of the 0.5 mm thin-walled specimen is significantly lower than that of the other two thicknesses of specimens at 850℃, exhibiting a significant thickness debit effect. In addition, the fatigue strengths of the 1.0 and 1.5 mm thin-walled specimens and the rotating bending fatigue specimens are close