Improving the transmission efficiency of central heating systems and reducing energy consumption are crucial for achieving energy-saving and emission-reduction targets, as well as improving economic benefits. At present, central heating is limited by the high temperature pipeline environment, where suitable pipeline drag reducers are lacking. Addressing this issue, this study experimentally investigates the drag reduction rate of cetyltrimethylammonium bromide/sodium salicylate (CTAB/NaSal), propyltrimonium erucate/sodium salicylate (ETAC/NaSal), octadecyl betaine/sodium salicylate (C₁₈-betaine/NaSal), and cetyl betaine/sodium salicylate (C₁₆-betaine/NaSal) in high-temperature and high-pressure circuits. The research findings indicate that a 600 mg/L solution of CTAB/NaSal (1∶1) achieves a drag reduction rate of up to 60% at temperatures ranging from 30 ℃ to 60 ℃; a 5000 mg/L solution of ETAC/NaSal (1∶1) exhibits drag reduction rates exceeding 50% between 40 ℃ and 90 ℃; a 2000 mg/L solution of C₁₈-betaine/NaSal (1∶1) effectively has drag reduction rates generally above 40% from 40 ℃ to 80 ℃; and a 4000 mg/L solution of C₁₆-betaine/NaSal (1∶1) maintains drag reduction rates mostly above 40% between 50 ℃ and 80 ℃. High temperatures and high flow rate can disrupt micellar structures, thereby reducing the drag-reducing performance of surfactants. Nevertheless, high-concentration solutions can partially mitigate the impact of drag reducer failure in high-temperature and high-pressure environments.