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| 钬激光消融凝胶结石组织的模型实验研究 |
| Model experiments on calculi tissue ablation induced by holmium laser |
| 投稿时间：2024-05-08 修订日期：2024-06-24 |
| DOI： |
| 中文关键词: 钬激光消融，凝胶-人造结石组织，模型实验，空化气泡 |
| 英文关键词:holmium laser ablation gelatin-artificial calculi tissue model experiments cavitation bubble |
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| 摘要点击次数: 141 |
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| 中文摘要: |
| 为探究钬激光消融人体内结石的动力学过程及对周遭组织的附带伤害,使用凝胶与石膏块模拟真实人体的软组织和结石,基于自主研制的钬激光器开展一系列钬激光消融凝胶-人造结石组织的模型实验,实验变量包括激光能量、光纤芯径和光纤距离人造结石的高度。首先通过消融过程的动态高速阴影成像观察,发现加载区域及附近的凝胶组织中出现葫芦状的空化气泡,并讨论了不同加载工况下空泡形态演化的不同机制。其次通过光学成像与扫描电子显微成像开展了回收凝胶与人造结石样品的表征,发现凝胶组织遭受的附带伤害主要来自烧蚀、空化、破碎和人造结石碎片溅射。另外发现人造结石消融坑内壁侧面与底部形貌显著不同,这与坑内不同区域经历的材料失效机制不同有关。最终通过白光干涉扫描获取了高精度的消融坑几何参数,并讨论了不同实验变量对消融坑几何参数的影响。通过能量分析归纳了消融过程中激光能量的去处,并发现消融坑体积与激光能量呈线性正相关。 |
| 英文摘要: |
| In order to investigate the dynamic process of calculi ablation by holmium (Ho) laser and its collateral damage to the surrounding tissues, various model experiments were conducted on artificial gelatin-gypsum samples, along with a homemade holmium laser device. The experimental parameters included the laser energy, the fiber diameter and the distance between fiber and artificial calculi. High-speed shadow graphs showed that an hourglass-shaped bubble would occur in gelatin during the ablation, and a discussion was provided on morphology evolution mechanism of hourglass-shaped bubbles under different loading conditions. Characterizations on the recovered samples were carried out via optical imaging and scanning electron microscope, the results revealed that gelatin tissue undergoes damage from erosion, cavitation and fragments jetting of artificial calculi. The ablation crater shows two kind of morphology on its side face and subface with different roughness due to different material failure mechanism. Geometric parameters of the ablation crater were obtained using white-light interferometry technique, along with discussions on the effects of loading conditions. Energy analysis were given on the ablation process,and a linear relation between crater volume and laser energy was evaluated. |
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