| 赵巍,侯振德*,任朝峰,毕平.骨细胞培养过程对羟基磷灰石力学性质影响的研究[J].实验力学,2009,24(1):1~7 |
| 骨细胞培养过程对羟基磷灰石力学性质影响的研究 |
| On the Influence of Osteoblastic Cell Culture on the Mechanical Properties of Hydroxyapatite |
| 投稿时间：2008-06-10 修订日期：2008-12-24 |
| DOI： |
| 中文关键词: 骨替代材料 羟基磷灰石 骨细胞 力学性质 图像相关 |
| 英文关键词:bone substitute materials hydroxyapatite osteoblastic cells mechanical property digital image correlation（DIC） |
| 基金项目:天津市应用基础研究计划资助项目（05YFJMJC10500） |
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| 中文摘要: |
| 采用数字图像相关方法研究骨细胞对人造羟基磷灰石力学性质的影响。采用了三种试样：羟基磷灰石试样、培养了骨细胞的羟基磷灰石试样、用戊二醛溶液浸泡的羟基磷灰石试样（与培养骨细胞同样环境但不培养骨细胞）。研究得到了试样完整的应力-应变曲线；同时测出弹性模量和泊松比，还测量了压缩极限应力。实验结果表明试样的应力-应变曲线在断裂前呈良好的线性关系；戊二醛溶液不影响羟基磷灰石的弹性模量和泊松比，但会使压缩极限应力降低；骨细胞培养过程能使羟基磷灰石材料的弹性模量和强度增加(所培养的骨细胞约占表面积3.75%)。对照显示，羟基磷灰石培养骨细胞后其弹性模量增加了15.2%，压缩极限应力增加了26.1%。 |
| 英文摘要: |
| Influence of osteoblast on the mechanical properties of hydroxyapatite was investigated by using digital image correlation technique (DIC). Three groups of sample were tested. They are hydroxyapatite, hydroxyapatite with osteoblasts and hydroxyapatite soaked in glutaral pentanedial solution without osteoblasts. Integral stress-strain curves of all three sample groups were obtained. Both Young’s modulus and Poisson ratio were obtained by DIC, and the limit pressure stress was also measured. Test results show that all three sample groups present a linear stress-strain relationship before sample fracture; glutaral pentanedial solution has no effect on Young’s modulus and Poisson’s ratio of hydroxyapatite, but reduces the value of limit pressure stress. Results also show that osteoblastic cell culture (osteoblastic cells take 3.75% surface area) increases 15.2% Young’s modulus and 26.1% compressive strength of hydroxyaptite respectively. |
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