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郑佳星,王丹凤,陈金龙,孙翠茹*.基于瑞利波光学相干断层扫描的非均质生物组织弹性测试技术[J].实验力学,2020,35(1):33~40
基于瑞利波光学相干断层扫描的非均质生物组织弹性测试技术
Heterogeneity biological tissue elastic measurement base on Rayleigh wave optical coherence tomography
投稿时间:2018-10-18  修订日期:2018-11-26
DOI:10.7520/1001-4888-18-301
中文关键词:  光学相干断层扫描(OCT)  瑞利波  弹性模量  相位分析
英文关键词:Optical coherence tomography (OCT)  Rayleigh wave  elastic modulus  phase analysis
基金项目:国家自然科学基金 (11602166, 11472187),天津市自然科学基金 (16JCYBJC40500)资助
作者单位
郑佳星 1.天津大学机械工程学院力学系 天津 300350 2.天津市现代工程力学重点实验室 天津 300350 
王丹凤 1.天津大学机械工程学院力学系 天津 300350 2.天津市现代工程力学重点实验室 天津 300350 
陈金龙 1.天津大学机械工程学院力学系 天津 300350 2.天津市现代工程力学重点实验室 天津 300350 
孙翠茹* 1.天津大学机械工程学院力学系 天津 300350 2.天津市现代工程力学重点实验室 天津 300350 
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中文摘要:
      生物组织的弹性可以为病理生理学的研究和疾病的诊疗提供重要信息,然而目前对结构复杂的生物组织各成分的弹性模量进行定量表征的技术较为匮乏。本文研究了基于瑞利波加载和光学相干断层扫描(OCT)对非均质生物组织的弹性进行定量测试的技术,提出了利用OCT探测瑞利波速度的实验技术和相位分析方法,进而通过瑞利波速度与介质弹性的关系获得了被测物体的弹性模量。结合瑞利波在分层介质中传播的频散特性,对分层仿体不同层的弹性进行了测试。将测得的仿体各成分的弹性模量与各成分单独的拉伸实验结果进行了比较,两种测试结果吻合较好,证明了基于瑞利波加载和OCT对分层生物组织弹性定量测试的可行性。本研究提出的瑞利波OCT弹性测试技术为非均质生物组织的弹性定量表征提供了简单有效的手段,具有应用于在体皮肤弹性测试的潜力。
英文摘要:
      Biological tissue elasticity can provide important information for the study of pathophysiology,the diagnosis and treatment of diseases. However, the quantitative characterization of the elastic modulus of the components of a complex structure is scarce currently. Based on Rayleigh wave loading and optical coherence tomography (OCT), we have quantitatively studied the elastic properties of heterogeneous biological tissues. An experimental and phase analysis method for detecting the propagation velocity of Rayleigh wave by OCT is proposed, and the elastic modulus of the measured object is obtained by the relationship between the velocity of Rayleigh wave propagation and the elasticity of the medium. Combining the dispersion characteristics of Rayleigh waves propagating in layered media, the elasticity of different layers of the layered phantom was tested.The elastic modulus of the measured components was compared with the tensile test results of each component. The results of the two tests are in good agreement, which proves the feasibility of quantitative measurement of the elasticity of layered biological tissues based on Rayleigh wave and OCT. The Rayleigh wave OCT elastic testing technology proposed in this study provides a simple and effective method for the quantitative characterization of nonhomogeneous biological tissues, and has the potential to be applied to in vivo skin elasticity testing.
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